Сегодня 22 августа 2019
Медикус в соцсетях
Задать вопрос

ЗАДАТЬ ВОПРОС РЕДАКТОРУ РАЗДЕЛА (ответ в течение нескольких дней)

Не публикуется
служит для обратной связи
Антиспам - не удалять!
Ваш вопрос:
Получать ответы и новости раздела
20 мая 2002 00:00   |   Harold L. Lazar, MD*a, Yusheng Bao, MDa, Samuel Rivers, BSa, Sheilah A. Bernard, MDa

Pretreatment with angiotensin-converting enzyme inhibitors attenuates ischemia-reperfusion injury

Background. The Heart Outcomes Prevention Evaluation (HOPE) trial demonstrated that ischemic events are decreased in patients receiving angiotensin-converting enzyme (ACE) inhibitors. This study sought to determine whether pretreatment with ACE inhibitors would attentuate ischemic injury during surgical revascularization of ischemic myocardium.
Methods. In a porcine model, the second and third diagonal vessels were occluded for 90 minutes, followed by 45 minutes of cardioplegic arrest, and 180 minutes of reperfusion. Ten pigs received quinapril (20 mg PO q.d.) for 7 days prior to surgery; 10 others received no-ACE inhibitors.
Results. Quinapril-treated animals required less cardioversions for ventricular arrhythmias (1.58 ± 0.40 vs 2.77 ± 0.22; p < 0.05), had higher wall motion scores assessed by two-dimensional echocardiography (4 = normal to -1 = dyskinesia; 2.11 ± 0.10 vs 1.50 ± 0.07; p < 0.05), more complete coronary artery endothelial relaxation to bradykinin (45% ± 3% vs 7% ± 4%; p < 0.005), and lower infarct size (24.0% ± 3.0% vs 40.0% ± 1.7%; p < 0.0001).
Conclusions. ACE inhibition prior to coronary revascularization enhances myocardial protection by decreasing ventricular irritability, improving regional wall motion, lowering infarct size, and preserving endothelial function.


Смотри также
20 мая 2002  |  00:05
Long-term survival and quality of life in cardiac surgical patients with prolonged intensive care unit length of stay
Background. Patients with prolonged intensive care unit (ICU) stays after cardiac operations are labor intensive and expensive. We sought to determine whether exhaustive ICU efforts result in
20 мая 2002  |  00:05
Endothelial cell injury induced by preservation solutions: a confocal microscopy study
Background. We evaluated the effects of standard preservation solutions on cultured human greater saphenous vein endothelial cells. Methods. Endothelial cells (eight strains) were preincubated
20 мая 2002  |  00:05
Catheter pericardiocentesis for delayed tamponade after cardiac valve operation
Background. Late tamponade is a rare cause of morbidity and mortality after cardiac valve operation. We describe our recent experience with this entity. Methods. This is a single institution,
20 мая 2002  |  00:05
Liberal use of delayed sternal closure for postcardiotomy hemodynamic instability
Background. The purpose of this retrospective study was to evaluate the current incidence, survival, and predictors of mortality for open chest management at our center. Methods. Our database
20 мая 2002  |  00:05
Treatment of end-stage heart disease with outpatient ventricular assist devices
Background. Initiating outpatient therapy with ventricular assist devices (VAD) was important in the progress of mechanical circulatory support. This article reviews our experience with VAD therapy