20 мая 2002 00:00 |
Liberal use of delayed sternal closure for postcardiotomy hemodynamic instability
Background. The purpose of this retrospective study was to evaluate the current incidence, survival, and predictors of mortality for open chest management at our center.
Methods. Our database was analyzed to identify adult postcardiotomy patients who left the operating room without primary sternal closure. Medical records were reviewed to determine mortality, postoperative complications, and pertinent hemodynamic data.
Results. From November 1997 to June 2000, 5,177 adults underwent cardiac procedures at our center. The incidence of open chest management was 1.7% (87 of 5,177), including 0.7% (16 of 2,254) for isolated coronary artery bypass grafting, 1.6% (15 of 912) for isolated valve, and 5.6% (47 of 839) for combined valve/coronary bypass. Hospital survival was 76% (66 of 87). Major complications included deep sternal infection (n = 4), stroke (n = 8), and dialysis (n = 13). Predictors of mortality by univariate analysis included ventricular assist device insertion (p = 0.003), new onset hemodialysis (p < 0.0005), reoperation for bleeding (p = 0.002), sternal infection (p = 0.042), mean length of delay before sternal closure (survivors = 3.2 days, nonsurvivors = 6.2 days; p = 0.031), higher mean dose of epinephrine at the time of chest closure (2.5 µg versus 0.9 µg, p = 0.011), and longer duration of high dose inotropic therapy (110 hours versus 43 hours, p = 0.002). Multivariate analysis showed ventricular assistance and reoperation for bleeding as independent predictors
Conclusions. Liberal use of open chest management is useful in patients with postcardiotomy shock, and can be carried out with a relatively low incidence of sternal complications. Patients who require ventricular assistance or exploration for ongoing mediastinal bleeding continue to have a high mortality rate.
20 мая 2002 | 00:05Catheter pericardiocentesis for delayed tamponade after cardiac valve operation
Background. Late tamponade is a rare cause of morbidity and mortality after cardiac valve operation. We describe our recent experience with this entity. Methods. This is a single institution,
20 мая 2002 | 00:05Treatment of end-stage heart disease with outpatient ventricular assist devices
Background. Initiating outpatient therapy with ventricular assist devices (VAD) was important in the progress of mechanical circulatory support. This article reviews our experience with VAD therapy
20 мая 2002 | 00:05Pretreatment with angiotensin-converting enzyme inhibitors attenuates ischemia-reperfusion injury
Background. The Heart Outcomes Prevention Evaluation (HOPE) trial demonstrated that ischemic events are decreased in patients receiving angiotensin-converting enzyme (ACE) inhibitors. This study
20 мая 2002 | 00:05Myocardial infarction scar plication in the rat: cardiac mechanics in an animal model for surgical procedures
Backgund. The immediate effects of surgical reduction of left ventricle cavity on cardiac mechanics have not been well defined. Methods. Cardiac mechanics were analyzed before and after myocardial
20 мая 2002 | 00:05BioGlue surgical adhesive impairs aortic growth and causes anastomotic strictures
Background. BioGlue surgical adhesive (CryoLife, Inc, Kennesaw, GA) is currently being used to secure hemostasis at cardiovascular anastomoses in adults. Interference with vessel growth would