Сегодня 14 октября 2019
Медикус в соцсетях
 
Задать вопрос

ЗАДАТЬ ВОПРОС РЕДАКТОРУ РАЗДЕЛА (ответ в течение нескольких дней)

Представьтесь:
E-mail:
Не публикуется
служит для обратной связи
Антиспам - не удалять!
Ваш вопрос:
Получать ответы и новости раздела
17 января 2002 00:00   |   Ani C. Anyanwu, MSc, MD, FRCSa, Tom Treasure, MD, MS, FRCSb

Unrealistic expectations arising from mortality data reported in the cardiothoracic journals

Background: This study was undertaken to ascertain whether mortality data in the cardiac surgical literature mirror data reported in national databases.
Methods: This was a review of articles with 50 or more subjects reporting single-center mortality data for coronary artery bypass or aortic or mitral valve replacement published in the three major cardiothoracic surgical journals from 1997 through 2000. Mortality data and trends were examined.
Results: One hundred sixty-nine articles were found (coronary artery bypass, n = 119; aortic valve replacement, n = 34; mitral valve replacement, n = 16). Articles were predominantly case series (N = 95), with smaller numbers of comparative retrospective studies (n = 34), randomized trials (n = 29), and prospective noncomparative studies (n = 11). The median mortality figures for these studies were 1.5% (interquartile range, 0.3%−2.6%) for coronary artery bypass, 3.4% (interquartile range, 2.0%−5.3%) for aortic valve replacement, and 4.7% (interquartile range, 2.1%−6.9%) for mitral valve replacement. In contrast, the national registry mortality figures were 2.9%, 4.0%, and 6.0%, respectively, in the United States and 2.6%, 4.5% and 6.3%, respectively, in the United Kingdom. Coronary bypass studies with samples smaller than 100 patients reported lower mortality figures (median 0%) than did those with more than 100 patients (1.8%). Exploration with graphical plots suggested a bias toward reporting and publication of studies with below average mortality.
Conclusions: Particularly for coronary artery bypass, published data tend to underrepresent the risk of death as seen in most centers. Outcomes and magnitudes of effects as reported in these research studies may not be replicable to the same degree in most centers. In particular, extreme caution should be taken in extrapolating results from studies with fewer than 100 patients to larger surgical populations.

Поделиться:




Комментарии
Смотри также
17 января 2002  |  00:01
Fractal or biologically variable delivery of cardioplegic solution prevents diastolic dysfunction after cardiopulmonary bypass
Fractal or biologically variable delivery of cardioplegic solution prevents diastolic dysfunction after cardiopulmonary bypass
17 января 2002  |  00:01
Determinants of maximal right ventricular function: Role of septal shift
Determinants of maximal right ventricular function: Role of septal shift
17 января 2002  |  00:01
Improved right heart function after myocardial preservation with 2,3-butanedione 2-monoxime in a porcine model of allogenic heart transplantation
Improved right heart function after myocardial preservation with 2,3-butanedione 2-monoxime in a porcine model of allogenic heart transplantation
17 января 2002  |  00:01
Surfactant function in lung transplantation after 24 hours of ischemia: Advantage of retrograde flush perfusion for preservation
Surfactant function in lung transplantation after 24 hours of ischemia: Advantage of retrograde flush perfusion for preservation
17 января 2002  |  00:01
Experimental study on size matching in a canine living-donor lobar lung transplant model
Experimental study on size matching in a canine living-donor lobar lung transplant model